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Preparing to treat the next pandemic, now.

Our Mission

The INTREPID Alliance exists to accelerate the development of new treatments for emerging viral pandemic agents through coordinated early science and R&D, policy and advocacy and stakeholder engagement.

Led by the biopharmaceutical industry and working with the public and private not-for-profit sectors, INTREPID will work to bridge key gaps and unmet needs to ensure delivery of antiviral solutions to viral pathogens with the greatest pandemic potential.

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The Intrepid Alliance will build upon lessons learned from the COVID pandemic so that the world is better prepared to tackle future emerging viral threats.”

John Young, PhD, VP and Global Head Infectious Disease, Roche Pharma Research and Early Development

It will take a breadth of new ideas and diverse approaches supported by effective collaborations to successfully tackle the daunting task of antiviral pandemic preparedness. That’s why we formed INTREPID: to facilitate the advancement of science, face the challenges and prepare for the future together.”

Tomas Cihlar, PhD, Senior Vice President Research, Virology, Gilead
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Luck is not a strategy. Humanity is likely to face new forms of respiratory pathogens that hold the potential to become pandemics – in our lifetime.”

Andy Plump, PhD, President, Research & Development, Takeda

SMALL MOLECULE ANTIVIRALS ARE NECESSARY

The emergence of SARS-COV-2, the virus that caused COVID-19, caught the world off-guard. It shouldn’t have.

Harbingers of infectious viral pandemics, such as the influenza H1N1, SARS, Zika, Ebola and MERS viruses had all emerged in the first two decades of the 21st century. Despite these devastating warnings, societies across the world still lacked promising therapeutic tools that could be rapidly and sustainably scaled at a global level when COVID-19 emerged.

Globalization, urban expansion, and exploitation of natural habitats suggest humanity will face new forms of respiratory pathogens that hold the potential to become pandemics. What we can’t predict is its lethality, timing and virulence. Vaccines and monoclonal antibodies proved effective against SARS-COV-2, however, their development, cost and scale have limited their use in many of the world’s most populous nations. Orally available small-molecule antiviral drugs for rapid mobilization and distribution are a critical tool to protect societies from a new viral pandemic. Unlike some vaccines and antibodies, antiviral therapies might be less prone to the impact of virus genetic evolution, may be effective against a broad range of viruses and can change the course of disease even after infection. Moreover, they generally are not subject to the same public distrust that has unfortunately prejudiced some against vaccines.

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History has shown efforts to prevent infectious epidemics wane after the immediate crisis ebbs. We can’t let history repeat itself again; we can do something to stop it.”

Elliott Levy, MD, Co-Founder

Intrepid Approach

Helping to fill the world’s medicine chest to prevent future global viral pandemics

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Addressing the threat of emerging pandemics would unequivocally demonstrate the social value of biopharma innovation and validate its innovation model.

In a pandemic, small-molecule antivirals can be used to reduce morbidity and mortality in infected patients, and slow the development and transmission of new variants escaping vaccines and neutralizing antibodies. Most small molecule antivirals can be produced rapidly and in a cost-effective manner at a global scale in existing facilities, but they require years to discover and develop, so research and development work must begin now.

Our efforts focus on catalyzing the development of therapeutic assets for coronavirus and other high-risk respiratory viral families, including those recognized by the World Health Organization (WHO) as posing a high risk of causing a pandemic.

The end result:

Across key sectors of the R &D ecosystem, a diverse portfolio of properly de-risked small-molecule therapies that can be immediately confirmed in late-stage trials if a high-risk pathogen begins to spread in humans.

How we achieve

Our mission

The INTREPID Alliance brings together three core activities to fill the gaps within today's pandemic preparedness ecosystem.

Our Model provides:

Enhanced early science collaboration: By working with partners in other sectors, members of the Alliance engage in early science collaboration, data sharing and capability development, to accelerate our understanding of viral targets and increase the likelihood of identifying promising chemical leads. We will maintain an up-to-date landscape analysis to identify gaps and unmet needs in the complex and evolving antiviral R&D ecosystem.

Stakeholder engagement: Align on unmet needs in pandemic preparedness identified by stakeholders and serve as a hub, convenor for cross sector engagement.

Policy and Advocacy: Work with governments, private, and philanthropic organizations that share our goals to shape a favorable legislative and regulatory environment for novel antivirals, increasing our ability to rapidly mobilize confirmed and authorized antivirals in the event of the next pandemic.

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SARS-CoV-2 demonstrated the vital importance of strong public-private partnerships for pandemic response. Ahead of the next pandemic, governments’ continued focus on preparedness through policy and regulatory innovation, funding for antiviral countermeasures development, and resilient health systems is essential. The Intrepid Alliance is committed to bringing the best science forward to achieve the goal of having effective medicines ready to deploy as soon as they’re needed.”

Lydia Ogden, Global Public Health R&D Policy and External Engagement Leader, J&J

Interested in Engaging with Intrepid?